Roger Federer SUI (1) vs. Novak Djokovic SRB (4). For the third consecutive year, Federer's path to the US Open title will go through Novak Djokovic, who was the last person to beat the Swiss great in a hard court semifinal, at the 2008 Australian Open. Federer beat Djokovic in Cincinnati on hard courts in two close sets just a few short weeks ago and knows how to get the job done in NYC. MadProfessah's pick: Federer in 4 sets.
Rafael Nadal ESP (3) vs. Juan Martín Del Potro ARG (6). This is Juan Martín's second Grand Slam semifinal this year and the 20-year-old is on a very steep learning curve. He has already shown that he can beat Nadal on hard courts, accomplishing that feat a few months ago in Canada. Nadal is not at 100% although he must be extremely motivated to get to his first career final in New York to cement his status as one of the all-time elite players by competing for (and completing) the career grand slam. MadProfessah's pick: del Potro in 5 sets.